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Cultural differences define diagnosis and genomic medicine practice: implications for undiagnosed diseases

null

《医学前沿(英文)》 2013年 第7卷 第3期   页码 389-394 doi: 10.1007/s11684-013-0281-3

摘要:

Despite the current acceleration and increasing leadership of Chinese genetics research, genetics and its clinical application have largely been imported to China from the Occident. Neither genetics nor the scientific reductionism underpinning its clinical application is integral to the traditional Chinese worldview. Given that disease concepts and their incumbent diagnoses are historically derived and culturally meaningful, we hypothesize that the cultural expectations of genetic diagnoses and medical genetics practice differ between the Occident and China. Specifically, we suggest that an undiagnosed diseases program in China will differ from the recently established Undiagnosed Diseases Program at the United States National Institutes of Health; a culturally sensitive concept will integrate traditional Chinese understanding of disease with the scientific reductionism of Occidental medicine.

关键词: genetics     cultural differences     undiagnosed diseases program    

Implement and Innovate Environmental Protection Measures, Promote Green Protection of Cultural Relics

Fu-qing Liang,Yong-ping Sun

《工程管理前沿(英文)》 2014年 第1卷 第4期   页码 330-335 doi: 10.15302/J-FEM-2014055

摘要: The subject is implementing and innovating environmental protection measures, and promoting green protection of cultural relics in the Three Gorges area. This thesis states its significance and effect in the beginning, and then summarizes seven pieces of main practice, includes five pieces of main effect. In the end, this thesis produces some relevant conclusions and suggestions about the subject.

关键词: environmental science     the Three Gorges cultural relics     innovate environmental protection measures     green protection    

Rare-earth separation based on the differences of ionic magnetic moment via quasi-liquid strategy

《化学科学与工程前沿(英文)》 2023年 第17卷 第10期   页码 1584-1594 doi: 10.1007/s11705-022-2189-4

摘要: The separation of rare earth elements is particularly difficult due to their similar physicochemical properties. Based on the tiny differences of ionic radius, solvent extraction has been developed as the “mass method” in industry with hundreds of stages, extremely intensive chemical consumption and large capital investments. The differences of the ionic magnetic moment among rare earths are greater than that of ionic radius. Herein, a novel method based on the large ionic magnetic moment differences of rare earth elements was proposed to promote the separation efficiency. Rare earths were firstly dissolved in the ionic liquid, then the ordering degree of them was improved with the Z-bond effect, and finally the magnetic moment differences between paramagnetic and diamagnetic rare earths in quasi-liquid system were enhanced. Taking the separation of Er/Y, Ho/Y and Er/Ho as examples, the results showed that Er(III) and Ho(III) containing ionic liquids had obvious magnetic response, while ionic liquids containing Y(III) had no response. The separation factors of Er/Y and Ho/Y were achieved at 9.0 and 28.82, respectively. Magnetic separation via quasi-liquid system strategy provides a possibility of the novel, green, and efficient method for rare earth separation.

关键词: rare earth element     different magnetic moment     magnetic separation     ionic liquid    

MHD effect on the critical temperature differences of oscillatory thermocapillary convection in two-layer

Hulin HUANG, Xiaoming ZHOU,

《能源前沿(英文)》 2010年 第4卷 第2期   页码 155-160 doi: 10.1007/s11708-009-0063-4

摘要: The effect of different directional magnetic fields on critical temperature differences of oscillatory thermocapillary convection in a rectangular cavity with differentially heated side walls filled with two viscous, immiscible, incompressible fluids is simulated in the absence of gravity. In this two-layer fluid system, the upper layer fluid is the electrically non-conducting encapsulant boron oxide (BO), while the lower one is the electrically conducting molten indium phosphide (InP). The interface between the two fluids is assumed to be flat and non-deformable. The computational results show that all the magnetic fields along the , and directions can delay the transition from steady convection to oscillatory convection, and critical temperature differences increase with an increasing Hartmann number. Furthermore, the effect of a magnetic field along the direction is strongest, followed by that along the direction, and that along the direction is the weakest for the same intensity of the magnetic field.

关键词: magnetohydrodynamic     magnetic fields     thermocapillary convection     critical temperature difference     oscillatory convection     two-layer fluid system    

Functional trait differences between native bunchgrasses and the invasive grass

Huiqin HE, Thomas A. MONACO, Thomas A. JONES

《农业科学与工程前沿(英文)》 2018年 第5卷 第1期   页码 139-147 doi: 10.15302/J-FASE-2017175

摘要: We conducted 30- and 60-d greenhouse experiments to compare functional traits of (invasive annual grass) and four perennial bunchgrasses under well-watered or drought conditions. Even under drought, experienced significantly less stress (i.e., higher xylem pressure potential and greater shoot water content, water use per day and water-use efficiency) and biomass production than the perennial grasses after 30 d. However, after 60 d, its superiority was reduced under infrequent watering. Differences among perennial grasses were more pronounced for physiological traits under infrequent watering and for morphological traits under frequent watering. (fast-growing species) had a higher transpiration rate, lower leaf temperature, and lower water-use efficiency than the other grasses after 30 d. In contrast, (slow-growing) had lower xylem pressure potential and higher leaf temperature than all other grasses under infrequent watering. Under frequent watering, shoot dry mass and specific leaf area of was matched by (moderate-growing species). Our results indicate that multiple-species plantings or seedings are necessary to foster greater weed resistance against . We also emphasize that when choosing plant material for restoration, performance during both pulse (resource-rich) and inter-pulse (resource-poor) periods should be considered.

关键词: annual grass     comparative growth     drought response     invasive plant     native grass     specific leaf area     soil-water use    

“一带一路”工程科技人文交流的基本内涵与企业参与现状

姚威 ,胡顺顺 ,牛丰

《中国工程科学》 2019年 第21卷 第4期   页码 111-117 doi: 10.15302/J-SSCAE-2019.04.017

摘要:

工程科技人文交流是人类改造或创造事物过程中不同科技知识和价值观等思想内容的交流过程,其目的是减少或消除不同国家间工程科技思想隔阂,增进民心相通,确保工程项目的顺利实施。本文从工程科技人文交流的内涵以及企业参与工程科技人文交流的重要意义出发,研究“一带一路”重点建设企业的工程科技人文交流现状,剖析企业参与工程科技人文交流存在的问题,进而对我国企业深度参与工程科技人文交流提出初步的建议。

关键词: “一带一路”     人文交流     工程科技     企业    

Multiphase redistribution differences of polycyclic aromatic hydrocarbons (PAHs) between two successive

Rufeng LI,Chenghong FENG,Dongxin WANG,Baohua LI,Zhenyao SHEN

《环境科学与工程前沿(英文)》 2016年 第10卷 第2期   页码 381-389 doi: 10.1007/s11783-015-0817-7

摘要: Successive sediment suspensions often happen in estuary, yet little research has probed into the difference in the release behaviors of organic compounds among different suspensions. This study took polycyclic aromatic hydrocarbons (PAHs) as typical organic contaminants and investigated the release behaviors between two successive suspensions with a particle entrainment simulator (PES). Results showed that successive sediment suspensions lowered the concentration of dissolved PAHs in the overlying water via facilitating the re-adsorption of dissolved PAHs onto the suspended particles. Fast-release and slow-release periods of PAHs were successively observed in the both suspensions. The concentration changes of dissolved PAHs in the second suspension were generally similar with but hysteretic to those in the first suspension. More vigorous desorption and re-absorption of PAHs were induced in the second suspension. Successive sediment suspensions obviously decreased the concentrations of mineral composition and organic matters in the overlying water, which significantly affects multiphase distribution of PAHs.

关键词: sediment suspension     PAHs     multiphase distribution     distribution coefficients    

秦巴文化旅游产业发展战略研究

张凡,胡永红,段德罡

《中国工程科学》 2016年 第18卷 第5期   页码 46-51 doi: 10.15302/J-SSCAE-2016.05.007

摘要:

秦巴山区既是世界级名山和华夏文明发源地,同时也是我国重要生态环境保护区和连片贫困地区之一,区内面临着经济发展与生态保护的矛盾。本文结合秦巴山区的文化旅游资源特点,顺应旅游产业发展趋势,提出了发展文化旅游产业、推动秦巴山区突破发展的基本思路。在分析秦巴文化旅游资源价值的基础上,文章明确了秦巴文化旅游产业发展的战略思路、战略目标、战略重点以及空间布局,并提出了秦巴文化旅游产业发展的对策建议。

关键词: 秦巴山区     文化旅游产业     发展战略    

Phosphate-induced differences in stabilization efficiency for soils contaminated with lead, zinc, and

Jie Ren, Zhuo Zhang, Mei Wang, Guanlin Guo, Ping Du, Fasheng Li

《环境科学与工程前沿(英文)》 2018年 第12卷 第2期 doi: 10.1007/s11783-018-1006-2

摘要: Phosphates can cost-effectively decrease the mobility of Pb in contaminated soils. However, Pb always coexists with other metals in soil, their competitive reactions with phosphates have not been tested. In this study, the abilities of KH PO , K HPO , and K PO to stabilize Pb, Zn, and Cd in soils contaminated with a single metal or a ternary metal for different phosphorus/metal molar ratios were investigated. Results indicated that the stabilization efficiency of KH PO , K HPO , and K PO for Pb, Zn, and Cd in single metal contaminated soil (P/M ratio 0.6) was 96.00%–98.74%, 33.76%–47.81%, and 9.50%–55.79%, respectively. Competitive stabilization occurred in the ternary system, Pb exhibited a strong competition, the stabilization efficiency of Zn and Cd reduced by 23.50%–31.64%, and 7.10%–39.26%, respectively. Pyromorphite and amorphous lead phosphate formed with excess KH PO or K HPO addition, while K PO resulted in the formation of a hydroxypyromorphite precipitate. Amorphous Zn and Cd phosphates and hydroxides were the primary products. The immobilization rate of Zn and Cd depends on pH, and increased significantly in response to the excess phosphate application. This approach provides insight into phosphate-induced differences in stabilization efficiency in soils contaminated with multiple metals, which is of theoretical and engineering significance.

关键词: Heavy metals     Metal-contaminated soil     Phosphate     Competitive stabilization    

公共文化建设项目应用公私伙伴关系模式的探讨

郭峰,蔡艺卿,王飞球

《中国工程科学》 2013年 第15卷 第11期   页码 108-112

摘要:

为改善我国公共文化建设项目的效率和提高公共文化服务水平,分析了公私伙伴关系(PPP)模式在公共文化建设项目的应用。本文研究对象是PPP模式在我国的应用现状和公共文化建设项目的特殊性,分析了PPP 模式在我国公共文化建设项目的适用性及优势,以宁波文化广场为例分析了PPP 模式的应用过程,并提出实现我国公共文化建筑PPP模式的几点建议。

关键词: PPP模式     公共文化建设项目     应用分析    

Visualization of amino acid composition differences between processed protein from different animal species

Xingfan ZHOU,Zengling YANG,Longjian CHEN,Lujia HAN

《农业科学与工程前沿(英文)》 2016年 第3卷 第2期   页码 171-179 doi: 10.15302/J-FASE-2016095

摘要: Amino acids are the dominant organic components of processed animal proteins, however there has been limited investigation of differences in their composition between various protein sources. Information on these differences will not only be helpful for their further utilization but also provide fundamental information for developing species-specific identification methods. In this study, self-organizing feature maps (SOFM) were used to visualize amino acid composition of fish meal, and meat and bone meal (MBM) produced from poultry, ruminants and swine. SOFM display the similarities and differences in amino acid composition between protein sources and effectively improve data transparency. Amino acid composition was shown to be useful for distinguishing fish meal from MBM due to their large concentration differences between glycine, lysine and proline. However, the amino acid composition of the three MBMs was quite similar. The SOFM results were consistent with those obtained by analysis of variance and principal component analysis but more straightforward. SOFM was shown to have a robust sample linkage capacity and to be able to act as a powerful means to link different sample for further data mining.

关键词: self-organizing feature maps     visualization     processed animal proteins (PAPs)     amino acid    

Gender differences in the relationship between plasma lipids and fasting plasma glucose in non-diabetic

null

《医学前沿(英文)》 2014年 第8卷 第4期   页码 477-483 doi: 10.1007/s11684-014-0346-y

摘要:

The association between dyslipidemia and elevated fasting glucose in type 2 diabetes is well known. In non-diabetes, whether this association still exists, and whether dyslipidemia is an independent risk factor for high fasting plasma glucose (FPG) levels are not clear. This cross-sectional study recruited 3460 non-diabetic Chinese subjects (1027 men, and 2433 women, aged 35–75 years old) who participated in a health survey. Men and women were classified into tertiles by levels of plasma lipids respectively. In women, the prevalence of impaired fasting glucose (IFG) was decreased with increased HDL-C. A stepwise increase in HDL-C was associated with decreasing FPG levels (lowest tertiles, FPG: 5.376±0.018; middle tertiles, 5.324±0.018; highest tertiles, 5.276±0.018 mmol/L; P=0.001). Reversely, FPG levels increased from lowest tertiles to highest tertiles of LDL-C, TC, and TG. we found that women in the first tertile with lower HDL-C level had a 1.75-fold increase in risk of IFG compared with non-diabetic women in the third tertile with higher HDL-C level (OR: 1.75; 95% CI: 1.20--2.56). In men, no significant association was found. We took age, BMI, waist/hip ratio, education, smoking, alcohol drinking, and physical exercise as adjusted variables. In Chinese non-diabetic women, dyslipidemia is independently associated with high levels of FPG; TG, HDL-C, and LDL-C are predictors of IFG independent of BMI and waist/hip ratio.

关键词: dyslipidemia     plasma lipids     plasma fasting glucose     impaired fasting glucose     non-diabetes    

Differences in distributions, assembly mechanisms, and putative interactions of AOB and NOB at a large

《环境科学与工程前沿(英文)》 2023年 第17卷 第10期 doi: 10.1007/s11783-023-1722-0

摘要:

● Nitrifiers in WWTP were investigated at large spatial scale.

关键词: Activated sludge     Spatial distributions     Microbial assembly     Co-occurrence patterns     Nitrifying bacteria    

Heterologous expression of signal protein 14-3-3 in and the subsequent immune response in mice

ZHENG Meijuan, SHEN Jilong, LUO Qingli, XU Yuanhong

《医学前沿(英文)》 2008年 第2卷 第1期   页码 95-99 doi: 10.1007/s11684-008-0017-y

摘要: Schistosomiasis japonica, a zoonosis caused by , is endemic to the Philippines and China. Several vaccine candidates have been identified and tested in different animal models, but it is still unclear which will be optimal for testing in the field. Therefore, new antigens and strategies are necessary for vaccine development against schistosomiasis japonica. The Sj14-3-3 gene was amplified and subcloned into the expression vector pPICZ?-B and transformed into X-33 by electroporation. Three transformants were induced with methanol. The cultural supernatant was collected and tested by SDS-PAGE and Western blotting. The protein of rSj14-3-3 was prepared and purified and BALB/c mice were immunized which was followed by a challenging infection. The immuno-protection was then evaluated. The Sj14-3-3 gene was expressed and secreted into the medium and its molecular weight was about 35000 as determined by SDS-PAGE. Western blotting showed that the protein had a high specificity against mouse-anti-Sj14-3-3 monoclonal antibody and rSj14-3-3 had a promising immune reactivity. The results of the immuno-protective experiments revealed that the worm reduction was 26.0%, 32.2%, and 36.8%, respectively. The number of eggs in liver tissue was reduced by 36.8%, 43.2%, and 46.1%, respectively. The recombinant Sj14-3-3 of eukaryotic expression in was successfully harvested. The molecular vaccine of Sj14-3-3 could partially induce resistance to the infection with in BALB/c mice. The recombinant protein Sj14-3-3 has promising immunological potentials for further approach to the diagnosis and development of molecular vaccine.

关键词: development     challenging     rSj14-3-3     resistance     cultural supernatant    

基于文化传承的微介入乡村规划策略研究

郭海鞍

《中国工程科学》 2019年 第21卷 第2期   页码 27-33 doi: 10.15302/J-SSCAE-2019.02.019

摘要:

长期以来,乡村规划一直沿袭城市规划设计的体系,以总图或鸟瞰图来表达对乡村规划的成果。很多地方政府一轮一轮做规划,但乡村风貌的改善效果甚微,这是因为忽视了乡村内在的文化传承问题,忽视了文化价值观的内在作用。源于城市的规划设计方法不能草率地划定乡村生活,因此需要研究一种与乡村文化传承相适应的规划设计理论。微介入规划理论是针对文化引导下的乡村复兴规划策略,基于一种小微渐进的方法,逐步实现乡村的改造与复兴,这种策略在当今大拆大改气势正盛的新一轮乡村规划进程中,显得尤为重要。

关键词: 乡村规划     微介入规划     推演、容错     乡村文化     乡村复兴    

标题 作者 时间 类型 操作

Cultural differences define diagnosis and genomic medicine practice: implications for undiagnosed diseases

null

期刊论文

Implement and Innovate Environmental Protection Measures, Promote Green Protection of Cultural Relics

Fu-qing Liang,Yong-ping Sun

期刊论文

Rare-earth separation based on the differences of ionic magnetic moment via quasi-liquid strategy

期刊论文

MHD effect on the critical temperature differences of oscillatory thermocapillary convection in two-layer

Hulin HUANG, Xiaoming ZHOU,

期刊论文

Functional trait differences between native bunchgrasses and the invasive grass

Huiqin HE, Thomas A. MONACO, Thomas A. JONES

期刊论文

“一带一路”工程科技人文交流的基本内涵与企业参与现状

姚威 ,胡顺顺 ,牛丰

期刊论文

Multiphase redistribution differences of polycyclic aromatic hydrocarbons (PAHs) between two successive

Rufeng LI,Chenghong FENG,Dongxin WANG,Baohua LI,Zhenyao SHEN

期刊论文

秦巴文化旅游产业发展战略研究

张凡,胡永红,段德罡

期刊论文

Phosphate-induced differences in stabilization efficiency for soils contaminated with lead, zinc, and

Jie Ren, Zhuo Zhang, Mei Wang, Guanlin Guo, Ping Du, Fasheng Li

期刊论文

公共文化建设项目应用公私伙伴关系模式的探讨

郭峰,蔡艺卿,王飞球

期刊论文

Visualization of amino acid composition differences between processed protein from different animal species

Xingfan ZHOU,Zengling YANG,Longjian CHEN,Lujia HAN

期刊论文

Gender differences in the relationship between plasma lipids and fasting plasma glucose in non-diabetic

null

期刊论文

Differences in distributions, assembly mechanisms, and putative interactions of AOB and NOB at a large

期刊论文

Heterologous expression of signal protein 14-3-3 in and the subsequent immune response in mice

ZHENG Meijuan, SHEN Jilong, LUO Qingli, XU Yuanhong

期刊论文

基于文化传承的微介入乡村规划策略研究

郭海鞍

期刊论文